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Proglycem (Diazoxide Capsules) and Thorazine (Chlorpromazine Tablets)

Determining the interaction of Proglycem (Diazoxide Capsules) and Thorazine (Chlorpromazine Tablets) and the possibility of their joint administration.

Check result:
Proglycem (Diazoxide Capsules) <> Thorazine (Chlorpromazine Tablets)
Relevance: 23.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using chlorproMAZINE together with diazoxide may increase your blood sugar levels and could cause your blood sugar levels to become too high. Symptoms of high blood sugar are increased thirst, increased hunger, and increased urination. You should contact your doctor if you experience loss of blood sugar control. You may need a dose adjustment or check your blood sugar more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Anecdotal information suggests that chlorpromazine may increase the hyperglycemic effect of diazoxide through an unknown mechanism. Both agents individually can cause hyperglycemia.

MANAGEMENT: Blood glucose levels should be closely monitored during concomitant therapy.

References
  • Aynsley-Green A, Illig R "Enhancement by chlorpromazine of hyperglycaemic action of diazoxide." Lancet 2 (1975): 658-9
Proglycem (Diazoxide Capsules)

Generic Name: diazoxide

Brand name: Proglycem, Hyperstat

Synonyms: Proglycem

Thorazine (Chlorpromazine Tablets)

Generic Name: chlorpromazine

Brand name: Thorazine, Ormazine, Thorazine Spansule

Synonyms: Thorazine (Injection), Thorazine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.