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Prograf and Verelan PM

Determining the interaction of Prograf and Verelan PM and the possibility of their joint administration.

Check result:

Prograf <> Verelan PM

Relevance: 01.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using tacrolimus together with verapamil may increase the effects of tacrolimus. Contact your doctor if you experience increased side effects such as fever, infection, diarrhea, tremor, headache, fatigue, or lethargy. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: In vitro data suggest that some calcium channel blockers inhibit the CYP450 3A4 hepatic metabolism and produce elevated blood levels of macrolide immunosuppressants. In healthy subjects, diltiazem 120 mg increased the maximum plasma concentration of sirolimus 1.4-fold and the AUC 1.6-fold. In contrast, limited information suggests that verapamil concentrations may also increase when coadministered with sirolimus.

MANAGEMENT: Careful monitoring of macrolide immunosuppressant and possibly calcium channel blocker blood concentrations is recommended if these drugs must be used together. Dose reductions of the immunosuppressant may be required.

References

Hebert MF, Lam AY "Diltiazem increases tacrolimus concentrations." Ann Pharmacother 33 (1999): 680-2
Seifeldin RA, Marcos-Alvarez A, Gordon FD, Lewis WD, Jenkins R "Nifedipine interaction with tacrolimus in liver transplant recipients." Ann Pharmacother 31 (1997): 571-5
Katari SR, Magnone M, Shapiro R, et al "Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients." Clin Transplant 11 (1997): 237-42
Iwasaki K, Matsuda H, Nagase K, Shiraga T, Tokuma Y, Uchida K "Effects of twenty-three drugs on the metabolism of FK506 by human liver microsomes." Res Commun Chem Pathol Pharmacol 82 (1993): 209-16
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Rapamune (sirolimus)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
Zimmerman JJ "Exposure-response relationships and drug interactions of sirolimus." AAPS J 6 (2004): e28
"Product Information. Prograf (tacrolimus)." Fujisawa, Deerfield, IL.
Cakaloglu Y, Tredger JM, Devlin J, Williams R "Importance of cytochrome p-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients." Hepatology 20 (1994): 309-16

Prograf

Generic Name: tacrolimus

Brand name: Prograf, Astagraf XL, Envarsus XR, Hecoria

Synonyms: n.a.

What is Prograf?

Verelan PM

Generic Name: verapamil

Brand name: Verelan PM, Calan, Calan SR, Isoptin SR, Verelan, Isoptin, Isoptin IV, Covera-HS

Synonyms: n.a.

What is Verelan PM?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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