Prograf Intravenous and Voraxaze

• Generic Name: tacrolimus
• Dosage Forms: capsule, gelatin coated; injection, solution
• Other Brand Names: Prograf, Astagraf XL, Envarsus XR, Hecoria

Tacrolimus injection is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Tacrolimus works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ.

Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is to be given only by or under the direct supervision of a doctor.

• Generic Name: glucarpidase
• Dosage Forms: injection, powder, for solution
• Other Brand Names: Voraxaze

Voraxaze (glucarpidase) is used in patients who develop kidney failure while receiving high doses of methotrexate (a chemotherapy drug).

Voraxaze is an enzyme that breaks down methotrexate in the body so the drug can be easily eliminated when the kidneys are not working properly.

Voraxaze may also be used for purposes not listed in this medication guide.