Prograf (Tacrolimus Granules for Suspension) and Renvela (Sevelamer Tablets)
Determining the interaction of Prograf (Tacrolimus Granules for Suspension) and Renvela (Sevelamer Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Sevelamer may reduce the blood levels and effects of tacrolimus. Contact your doctor if your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with sevelamer may reduce blood levels of oral cyclosporine, mycophenolate mofetil, and tacrolimus. The mechanism is reduction of absorption by sevelamer. Concomitant use of sevelamer with mycophenolate mofetil in adult and pediatric patients decreased the mean Cmax and AUC of mycophenolic acid (MPA) by 36% and 26%, respectively. Adverse effects, such as graft rejection in transplant patients, have not been reported. Data are lacking for an interaction with other phosphate binders.
MANAGEMENT: The immunosuppressant may be given at least 1 to 2 hours before or 2 to 3 hours after sevelamer administration to minimize the impact on absorption. It is recommended to closely monitor blood concentrations of the immunosuppressant during concomitant use and after discontinuation of sevelamer.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories, Nutley, NJ.
- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
Generic Name: tacrolimus
Brand name: Prograf, Astagraf XL, Envarsus XR, Hecoria
Synonyms: Prograf
Generic Name: sevelamer
Brand name: Renagel, Renvela
Synonyms: Renvela
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Prograf (Tacrolimus Granules for Suspension)-ReoPro
- Prograf (Tacrolimus Granules for Suspension)-Repaglinide
- Prograf (Tacrolimus Granules for Suspension)-Repaglinide and Metformin
- Prograf (Tacrolimus Granules for Suspension)-Repaglinide and Metformin Tablets
- Prograf (Tacrolimus Granules for Suspension)-Repaglinide Tablets
- Prograf (Tacrolimus Granules for Suspension)-Repan
- Renvela (Sevelamer Tablets)-Prograf (Tacrolimus Injection)
- Renvela (Sevelamer Tablets)-Prograf Intravenous
- Renvela (Sevelamer Tablets)-Prohance
- Renvela (Sevelamer Tablets)-ProHance Injection
- Renvela (Sevelamer Tablets)-Prohist LQ
- Renvela (Sevelamer Tablets)-Prolensa