Prograf (Tacrolimus Injection) and Valcyte

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using valGANciclovir together with tacrolimus. Combining these medications may increase the risk of kidney, nerve damage, and/or side effects that affect your bone marrow function, resulting in low numbers of different types of blood cells. You may be more likely to develop anemia, bleeding problems, or infections due to low blood cell counts. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek medical attention if you experience signs and symptoms that may suggest kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Be sure to drink plenty of fluids if you develop diarrhea or vomiting during treatment with these medications, as dehydration can also harm the kidney. In addition, let your doctor know if you develop seizures; hearing problems; or numbness, burning or tingling in your hands and feet. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The concurrent or sequential use of tacrolimus and ganciclovir may increase the risk of toxicities such as myelotoxicity, nephrotoxicity, and neurotoxicity. Patients who are debilitated, dehydrated, or who have preexisting renal dysfunction may be at a greater risk of developing adverse reactions.

MANAGEMENT: Some authorities advise that these medicines should be coadministered only if the benefits are anticipated to outweigh the potential risks. If concomitant use is required, close clinical and laboratory monitoring of renal and neurologic function and drug serum concentrations (if clinically appropriate) as well as for the development of severe hematologic adverse effects is recommended.

Prograf (Tacrolimus Injection)

Generic Name: tacrolimus

Brand name: Prograf, Astagraf XL, Envarsus XR, Hecoria

Synonyms: Prograf

What is Prograf (Tacrolimus Injection)?

Valcyte

Generic Name: valganciclovir

Brand name: Valcyte

Synonyms: n.a.

What is Valcyte?