Promethazine Hydrochloride and Seconal
Determining the interaction of Promethazine Hydrochloride and Seconal and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using secobarbital together with promethazine can alter the drug levels and effects of both medications. Contact your doctor if you experience slow or shallow breathing, extreme sleepiness, hypotension or a convulsion. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Concomitant use of phenothiazines with barbiturates may reduce the plasma concentrations and therapeutic effects of both agents. The mechanism is unclear but may relate to metabolic induction of CYP450 hepatic enzymes. In addition, coadministration of phenothiazines and barbiturates may lead to a reduction in seizure threshold and additive central nervous system (CNS) and respiratory depressant effects.
MANAGEMENT: Administration of phenothiazines in patients receiving large doses of barbiturates is considered contraindicated by some authorities (US). If coadministration is required, caution as well as clinical and laboratory monitoring should be considered whenever either of these agents is added to or withdrawn from therapy. If chlorpromazine is coadministered with a barbiturate, the manufacturer of chlorpromazine recommends using 1/4 to 1/2 of the usual barbiturate dosage. Patients should be monitored for hypotension, loss of seizure control and the development of adverse effects including CNS and respiratory depression.
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- "Product Information. Thioridazine Hydrochloride (thioridazine)." Mylan Institutional (formerly UDL Laboratories), Rockford, IL.
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- "Product Information. Trifluoperazine Hydrochloride (trifluoperazine)." Mylan Institutional (formerly UDL Laboratories), Rockford, IL.
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Generic Name: promethazine
Brand name: Phenergan, Phenadoz, Promethegan
Synonyms: Promethazine
Generic Name: secobarbital
Brand name: Seconal, Seconal Sodium
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Promethazine Hydrochloride-Seconal Sodium
- Promethazine Hydrochloride-SecreFlo
- Promethazine Hydrochloride-Secretin
- Promethazine Hydrochloride-Secretin Intravenous
- Promethazine Hydrochloride-Sectral
- Promethazine Hydrochloride-Secukinumab
- Seconal-Promethazine injection
- Seconal-Promethazine Injection, Intravenous
- Seconal-Promethazine rectal
- Seconal-Promethazine Suppositories
- Seconal-Promethazine Syrup
- Seconal-Promethazine Tablets