Pronestyl injection and Trimethoprim
Determining the interaction of Pronestyl injection and Trimethoprim and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using procainamide together with trimethoprim may increase the effects of procainamide. Contact your doctor if you experience tiredness, dizziness, fainting, confusion, tremor, difficulty breathing, and an irregular heartbeat. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Trimethoprim may decrease the renal secretion of procainamide. Serum procainamide levels may be increased.
MANAGEMENT: Serum procainamide and NAPA levels should be checked during therapy, and procainamide dosage should be decreased, if necessary. Patients should be advised to promptly notify their physician if they experience drowsiness, dizziness, syncope, confusion, tremor, or palpitations.
- Harron D, Brogden R "Acecaindie (N-acetylprocainamide)." Drugs 39 (1990): 720-40
- Kosoglou T, Rocci M, Vlasses P "Trimethoprim alters the disposition of procainamide and N-acetylprocainamide." Clin Pharmacol Ther 44 (1988): 467-77
- Vlasses P, Kosoglou T, Chase S, et al "Trimethoprim inhibition of the renal clearance of procainamide and N-acetylprocainamide." Arch Intern Med 149 (1989): 1350-3
Generic Name: procainamide
Brand name: Pronestyl, Procan SR, Pronestyl-SR, Procanbid
Synonyms: Pronestyl (injection), Pronestyl
Generic Name: trimethoprim
Brand name: Primsol, Trimpex, Proloprim
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Pronestyl injection-Trimethoprim Oral Solution
- Pronestyl injection-Trimethoprim Tablets
- Pronestyl injection-Trimipramine
- Pronestyl injection-Trimipramine Capsules
- Pronestyl injection-Trimipramine Maleate
- Pronestyl injection-Trimo San Jelly
- Trimethoprim-Pronestyl-SR
- Trimethoprim-Pronutrients Vitamin D3
- Trimethoprim-Propa pH Acne Med Cleansing
- Trimethoprim-Propa pH Topical
- Trimethoprim-Propafenone
- Trimethoprim-Propafenone Extended Release Capsule