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Propafenone Extended Release Capsule and Seconal Sodium

Determining the interaction of Propafenone Extended Release Capsule and Seconal Sodium and the possibility of their joint administration.

Check result:
Propafenone Extended Release Capsule <> Seconal Sodium
Relevance: 19.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Some barbiturates increase the hepatic metabolism of propafenone. Plasma levels and efficacy of propafenone may be decreased. Data are available for phenobarbital. Propafenone efficacy should be monitored during coadministration, and plasma propafenone levels should be checked as necessary. It may be necessary to increase propafenone dosage.

References
  • Chan GL, Axelson JE, Kerr CR "The effect of phenobarbital on the pharmacokinetics of propafenone in man." Pharm Res 5 (1988): s153
Propafenone Extended Release Capsule

Generic Name: propafenone

Brand name: Rythmol, Rythmol SR

Synonyms: Propafenone

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.