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Propafenone Hydrochloride and Rifadin

Determining the interaction of Propafenone Hydrochloride and Rifadin and the possibility of their joint administration.

Check result:

Propafenone Hydrochloride <> Rifadin

Relevance: 09.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using rifAMPin together with propafenone may decrease the effects of propafenone. Contact your doctor if you experience worsening of an irregular heartbeat, chest tightness, blurred vision, nausea, of if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rifampin may significantly decrease plasma concentrations of propafenone by inducing its CYP450 hepatic metabolism. Reductions in propafenone half-life, twofold increases in clearance, and reductions in bioavailability have been reported. Therapeutic failure may occur.

MANAGEMENT: The patient should be monitored for inadequate response to propafenone and subtherapeutic plasma concentrations. Maximum effects of the interaction may not be apparent for 2 weeks after rifampin is initiated or discontinued. Dosage should be adjusted as necessary. Patients should be advised to promptly notify their physician if they experience a return of their arrhythmia (i.e., syncope, palpitations, irregular heartbeats).

References

Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6
Castel JM, Cappiello E, Leopaldi D, Latini R "Rifampicin lowers plasma concentrations of propafenone and its antiarrhythmic effect." Br J Clin Pharmacol 30 (1990): 155-6
Dilger K, Hofman U, Klotz U "Enzyme induction in the elderly: Effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone." Clin Pharmacol Ther 67 (2000): 512-20

Propafenone Hydrochloride

Generic Name: propafenone

Brand name: Rythmol, Rythmol SR

Synonyms: Propafenone

What is Propafenone Hydrochloride?

Rifadin

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rifadin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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