Propranolol Injection and Tagrisso
Determining the interaction of Propranolol Injection and Tagrisso and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Osimertinib may reduce the blood levels and effects of propranolol. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with osimertinib may decrease the plasma concentrations of drugs that are primarily metabolized by CYP450 1A2. In vitro, osimertinib has been shown to be an inducer of the isoenzyme. However, no pharmacokinetic data are available from drug interaction studies.
MANAGEMENT: Caution is advised when osimertinib is prescribed with drugs that undergo metabolism by CYP450 1A2. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever osimertinib is added to or withdrawn from therapy. Sensitive CYP450 1A2 substrates or substrates with narrow therapeutic ranges (e.g., theophylline) should preferably be avoided with osimertinib, if possible.
- "Product Information. Tagrisso (osimertinib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: propranolol
Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL
Synonyms: Propranolol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Propranolol Injection-Take Action
- Propranolol Injection-Talacen
- Propranolol Injection-Talazoparib
- Propranolol Injection-Talazoparib Tosylate
- Propranolol Injection-Talimogene laherparepvec
- Propranolol Injection-Talimogene laherparepvec Injection
- Tagrisso-Propranolol Intravenous
- Tagrisso-Propranolol Oral Solution
- Tagrisso-Propranolol Oral Solution (Hemangeol)
- Tagrisso-Propranolol Sustained-Release Bead Capsules
- Tagrisso-Propranolol Sustained-Release Capsules
- Tagrisso-Propranolol Tablets