Prostin E2 and Syntocinon

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using oxytocin together with dinoprostone topical can increase your response to oxytocin and increase your risk of additional uterine problems or lead to uterine rupture. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Prostaglandins, especially those of the E type, may potentiate the uterine response to oxytocin and increase the risk of uterine hyperstimulation and rupture. The mechanism of interaction is unknown.

MANAGEMENT: Infusion of oxytocin should not be started until at least 6 to 12 hours after the use of dinoprostone vaginal gel (6 to 12 hours recommended for Prepidil Gel and 12 to 24 hours for Prostin E2 Vaginal Gel) or at least 30 minutes after the removal of dinoprostone vaginal insert.

Prostin E2

Generic Name: dinoprostone topical

Brand name: Cervidil, Prepidil, Prostin E2

Synonyms: n.a.

What is Prostin E2?

Syntocinon

Generic Name: oxytocin

Brand name: Pitocin, Syntocinon

Synonyms: n.a.

What is Syntocinon?