Prothrombin Complex Concentrate and Sandostatin LAR

• Generic Name: prothrombin complex
• Dosage Forms: n.a.
• Other Brand Names: Kcentra

Used for the urgent reversal of vitamin K antagonist (e.g., warfarin) anticoagulation in adults with acute major bleeding; designated an orphan drug by FDA for this use.

Rapidly restores vitamin K-dependent coagulation factors that are depleted by warfarin therapy.

Use in conjunction with vitamin K (phytonadione) to maintain adequate levels of coagulation factors once the effects of prothrombin complex concentrate (human) have diminished.

Experts generally consider PCCs such as prothrombin complex concentrate (human) (Kcentra) to be a reasonable (and in some cases, preferred) alternative to fresh frozen plasma for the urgent reversal of anticoagulation in patients with warfarin-induced bleeding. May provide some advantages over plasma including more rapid INR reduction, reduced drug preparation time, reduced risk of anaphylaxis and transmission of infectious pathogens, and lower drug volumes (which may be beneficial in patients with fluid restrictions).

Not indicated for the urgent reversal of vitamin K antagonist anticoagulation in patients without acute major bleeding.

• Generic Name: octreotide
• Dosage Forms: injection
• Other Brand Names: Sandostatin, Sandostatin LAR Depot

Octreotide is a man-made protein that is similar to a hormone in the body called somatostatin. Octreotide lowers many substances in the body such as insulin and glucagon (involved in regulating blood sugar), growth hormone, and chemicals that affect digestion.

Octreotide is used to treat acromegaly. Octreotide is also used to reduce flushing episodes and watery diarrhea caused by cancerous tumors (carcinoid syndrome) or tumors called vasoactive intestinal peptide tumors (VIP adenomas).

Octreotide may also be used for purposes not listed in this medication guide.