Prothrombin Complex Concentrate and Smallpox vaccine Injection

• Generic Name: prothrombin complex
• Dosage Forms: n.a.
• Other Brand Names: Kcentra

Used for the urgent reversal of vitamin K antagonist (e.g., warfarin) anticoagulation in adults with acute major bleeding; designated an orphan drug by FDA for this use.

Rapidly restores vitamin K-dependent coagulation factors that are depleted by warfarin therapy.

Use in conjunction with vitamin K (phytonadione) to maintain adequate levels of coagulation factors once the effects of prothrombin complex concentrate (human) have diminished.

Experts generally consider PCCs such as prothrombin complex concentrate (human) (Kcentra) to be a reasonable (and in some cases, preferred) alternative to fresh frozen plasma for the urgent reversal of anticoagulation in patients with warfarin-induced bleeding. May provide some advantages over plasma including more rapid INR reduction, reduced drug preparation time, reduced risk of anaphylaxis and transmission of infectious pathogens, and lower drug volumes (which may be beneficial in patients with fluid restrictions).

Not indicated for the urgent reversal of vitamin K antagonist anticoagulation in patients without acute major bleeding.

• Generic Name: smallpox vaccine
• Dosage Forms: n.a.
• Other Brand Names:

Smallpox vaccine is an active immunizing agent used to prevent smallpox infection. It works by causing your immune system to produce its own protection (antibodies) against the virus .

This vaccine should only be administered by or under the supervision of your doctor or another health care professional .

Smallpox vaccine is available only with a doctor's prescription .