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Prozac Weekly and Seldane

Determining the interaction of Prozac Weekly and Seldane and the possibility of their joint administration.

Check result:

Prozac Weekly <> Seldane

Relevance: 18.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Terfenadine is no longer on the market in the US. Do not take terfenadine with any other medication.

Professional:

GENERALLY AVOID: Theoretical concerns and one case report have suggested that coadministration of fluoxetine and terfenadine or astemizole may be associated with cardiotoxic effects, including prolongation of the QT interval. The mechanism probably is related to the inhibition of terfenadine and astemizole metabolism by fluoxetine or norfluoxetine, which is a potent inhibitor of CYP450 3A4. Other selective serotonin reuptake inhibitors (SSRIs) may interact with terfenadine and astemizole in a similar manner.

MANAGEMENT: If terfenadine or astemizole must be used with an SSRI, caution and close observation for evidence of cardiotoxicity are recommended.

References

Swims MP "Potential terfenadine-fluoxetine interaction." Ann Pharmacother 27 (1993): 1404-5
Vonmoltke LL, Greenblatt DJ, Duan SX, Harmatz JS, Wright CE, Shader RI "Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo." J Clin Psychopharmacol 16 (1996): 104-12
Marchiando RJ, Cook MD "Probable terfenadine-fluoxetine-associated cardiac toxicity." Ann Pharmacother 29 (1995): 937-8

Prozac Weekly

Generic Name: fluoxetine

Brand name: Prozac, Prozac Weekly, Sarafem, PROzac Pulvules, Rapiflux, Selfemra

Synonyms: n.a.

What is Prozac Weekly?

Seldane

Generic Name: terfenadine

Brand name: Seldane

Synonyms: n.a.

What is Seldane?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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