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Prucalopride Succinate and Zovia 1/50e

Determining the interaction of Prucalopride Succinate and Zovia 1/50e and the possibility of their joint administration.

Check result:
Prucalopride Succinate <> Zovia 1/50e
Relevance: 06.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Blood levels and effects of oral contraceptives may be reduced if severe diarrhea occurs during treatment with prucalopride. This may increase the risk of breakthrough bleeding and unintended pregnancy. You should use an additional method of birth control if you experience severe diarrhea while taking prucalopride. If diarrhea is persistent, stop taking prucalopride and contact your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADDITIONAL CONTRACEPTION RECOMMENDED: The efficacy of oral contraceptives may be reduced if severe diarrhea occurs with prucalopride treatment. However, prucalopride itself has no clinically significant effect on the pharmacokinetics of oral contraceptives based on data reported for ethinyl estradiol and norethindrone in healthy study subjects.

MANAGEMENT: In patients who develop severe diarrhea during treatment with prucalopride, the use of an additional contraceptive method is recommended to prevent possible failure of oral contraception. If severe or persistent diarrhea occurs, patients should be advised to stop taking prucalopride and consult their physician.

References
  • Cerner Multum, Inc. "Australian Product Information." O 0
  • "Product Information. Resotran (prucalopride)." Janssen Pharmaceuticals, Titusville, NJ.
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Prucalopride Succinate

Generic Name: prucalopride

Brand name: Motegrity

Synonyms: Prucalopride

Zovia 1/50e

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/50, Zovia 1/50E

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction