Puralor Ci and Questran Light
Determining the interaction of Puralor Ci and Questran Light and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using cholestyramine together with multivitamin with minerals may decrease the effects of multivitamin with minerals. Multivitamin with minerals should be administered at least 4 hours before cholestyramine. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies, rats administered colesevelam at doses greater than 30-fold the projected human clinical dose developed hemorrhage in association with vitamin K deficiency. In a crossover study involving healthy subjects, coadministration of sevelamer with calcitriol resulted in a significant reduction in bioavailability for calcitriol (calcitriol with sevelamer vs calcitriol alone: AUC 137 pg*h/mL vs 318 pg*h/mL and Cmax 40.1 pg/mL vs 49.7 pg/mL, respectively).
MANAGEMENT: Oral vitamin supplements should be administered at least 4 hours before colesevelam and either 1 hour before or 4 to 6 hours after other bile acid sequestrants and sevelamer.
- Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.
Generic Name: multivitamin with minerals
Brand name: Berocca Plus, Vicon Forte, Prosteon, TheraCal D200, TheraCal D400, Geritol Tonic, SSS. Tonic, Vitalize, Fovex
Synonyms: Calcium-Folic Acid Plus D, Multivitamins and minerals
Generic Name: cholestyramine
Brand name: Prevalite, Questran, Questran Light, Cholestyramine Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Puralor Ci-Quetiapine
- Puralor Ci-Quetiapine Extended-Release Tablets
- Puralor Ci-Quetiapine Fumarate
- Puralor Ci-Quetiapine Fumarate Tablets
- Puralor Ci-Quetiapine Fumarate XR Tablets
- Puralor Ci-Quetiapine Tablets
- Questran Light-PureFe Plus
- Questran Light-Purelax
- Questran Light-PureVit DualFe Plus
- Questran Light-Purinethol
- Questran Light-Purixan
- Questran Light-Puroxcin