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Pyrazinamide and Zyloprim

Determining the interaction of Pyrazinamide and Zyloprim and the possibility of their joint administration.

Check result:

Pyrazinamide <> Zyloprim

Relevance: 28.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Pyrazinamide may render allopurinol less effective. Allopurinol inhibits the renal excretion of pyrazinamide metabolites, which, in turn, inhibit uric acid excretion. During concomitant therapy, it is recommended that the patient be closely monitored for reduced allopurinol efficacy.

References

Lacroix C, Guyonnaud C, Chaou M, Duwoos H, Lafont O "Interaction between allopurinol and pyrazinamide." Eur Respir J 1 (1988): 807-11

Pyrazinamide

Generic Name: pyrazinamide

Brand name:

Synonyms: n.a.

What is Pyrazinamide?

Zyloprim

Generic Name: allopurinol

Brand name: Zyloprim, Lopurin, Aloprim

Synonyms: n.a.

What is Zyloprim?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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