Pyridoxine Hydrochloride Injection and Sinemet
Determining the interaction of Pyridoxine Hydrochloride Injection and Sinemet and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using levodopa together with pyridoxine. Pyridoxine may decrease the effects of levodopa resulting in less levodopa available for your body to use. You should be advised against taking pyridoxine-containing vitamin supplements. If your doctor prescribes these medications together, you may need a dose adjustment to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Pyridoxine doses of 5 mg/day or more antagonise the effects of levodopa. In the presence of pyridoxine, the peripheral metabolism of levodopa to dopamine is increased, resulting in less levodopa available to enter the CNS. The dopa-decarboxylase inhibitors carbidopa and benserazide reduce the peripheral metabolism of levodopa, even in the presence of high concentrations of pyridoxine, allowing more levodpa to enter the CNS.
MANAGEMENT: The concomitant use of pyridoxine and levodopa without dopa-decarboxylase inhibitors should be avoided. Patients should be advised against taking pyridoxine-containing vitamin supplements.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Diclectin (doxylamine-pyridoxine)." Duchesnay Inc, Laval, IN.
Generic Name: pyridoxine
Brand name: Vitamin B6, Vitelle Nestrex, Pyridoxal 5'-Phosphate
Synonyms: Pyridoxine
Generic Name: carbidopa / levodopa
Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Pyridoxine Hydrochloride Injection-Sinemet 10-100
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- Pyridoxine Hydrochloride Injection-Sinemet 25-250
- Pyridoxine Hydrochloride Injection-Sinemet 250/25
- Sinemet-Pyridoxine Oral, Injection
- Sinemet-Pyril D Suspension
- Sinemet-Pyril DM Suspension
- Sinemet-Pyril Mal Phenyl HCl
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