Pyridoxine (Vitamin B6) Extended-Release Tablets and Stalevo 150

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using levodopa together with pyridoxine. Pyridoxine may decrease the effects of levodopa resulting in less levodopa available for your body to use. You should be advised against taking pyridoxine-containing vitamin supplements. If your doctor prescribes these medications together, you may need a dose adjustment to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Pyridoxine doses of 5 mg/day or more antagonise the effects of levodopa. In the presence of pyridoxine, the peripheral metabolism of levodopa to dopamine is increased, resulting in less levodopa available to enter the CNS. The dopa-decarboxylase inhibitors carbidopa and benserazide reduce the peripheral metabolism of levodopa, even in the presence of high concentrations of pyridoxine, allowing more levodpa to enter the CNS.

MANAGEMENT: The concomitant use of pyridoxine and levodopa without dopa-decarboxylase inhibitors should be avoided. Patients should be advised against taking pyridoxine-containing vitamin supplements.

Pyridoxine (Vitamin B6) Extended-Release Tablets

Generic Name: pyridoxine

Brand name: Vitamin B6, Vitelle Nestrex, Pyridoxal 5'-Phosphate

Synonyms: Pyridoxine

What is Pyridoxine (Vitamin B6) Extended-Release Tablets?

Stalevo 150

Generic Name: carbidopa / entacapone / levodopa

Brand name: Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75, Stalevo

Synonyms: n.a.

What is Stalevo 150?