Qualaquin and Theo-Dur

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using quiNINE together with theophylline may affect the blood levels and effects of both medications. Specifically, quiNINE levels may increase and theophylline levels may decrease. Let your doctor know if your conditions worsen or you experience increased side effects of quiNINE such as headache, flushing, sweating, nausea, vomiting, diarrhea, abdominal pain, dizziness, ringing in the ears, hearing impairment, blurred vision, vision impairment, and irregular heart rhythm. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of theophylline and quinine has resulted in slightly decreased serum concentrations of theophylline and increased concentrations of quinine. The mechanism of interaction has not been established. When quinine (648 mg every 8 hours x 7 days) was administered with a single 300 mg oral dose of theophylline to healthy volunteers, mean theophylline peak plasma concentration (Cmax) did not change while systemic exposure (AUC) decreased by 10%. In contrast, mean quinine Cmax and AUC were increased by 13% and 14%, respectively. The clinical significance of these changes is unknown.

MANAGEMENT: Caution is advised during concomitant use of theophylline and quinine. Serum theophylline levels should be monitored frequently to ensure therapeutic concentrations, and patients should be monitored for adverse reactions associated with quinine such as hematologic toxicities and cardiac arrhythmias including torsade de pointes and atrial fibrillation. Patients should be advised to contact their physician if they experience increased side effects such as headache, flushing, sweating, nausea, vomiting, diarrhea, abdominal pain, tinnitus, dizziness, vertigo, hearing impairment, blurred vision, vision impairment, and irregular heart rhythm.

Qualaquin

Generic Name: quinine

Brand name: Qualaquin, QM-260, Quinamm

Synonyms: n.a.

What is Qualaquin?

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?