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Qudexy XR and Tegretol

Determining the interaction of Qudexy XR and Tegretol and the possibility of their joint administration.

Check result:

Qudexy XR <> Tegretol

Relevance: 27.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Before taking carBAMazepine, tell your doctor if you also use topiramate. You may need dose adjustments or special tests in order to safely take both medications together. This combination may affect the topiramate blood levels in your body. You should notify your doctor if your seizure control changes or worsens. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

ADJUST DOSE: Carbamazepine, when coadministered with topiramate may lead to a 40% decrease in the plasma concentration of topiramate. The mechanism appears to be hepatic enzyme induction with subsequent increased metabolism of topiramate. In contrast, some evidence suggests that toxicity may occur when topiramate is added to the maximum tolerated doses of carbamazepine.

MANAGEMENT: If dosages of topiramate have been adjusted upward, reduction or withdrawal of carbamazepine during adjunctive therapy may require a downward dose adjustment of topiramate. In general, no adjustment in carbamazepine dosage is required when topiramate adjunctive therapy is started; however, if toxicity develops when topiramate is added to the maximum tolerated dose of carbamazepine, a reduction in the carbamazepine dose should be considered. Patients should be monitored for altered efficacy and safety and should be advised to notify their physician if seizure control worsens or adverse effects occur.

References

Sachdeo RC, Sachdeo SK, Walker SA, Kramer LD, Nayak RK, Doose DR "Steady-state pharmacokinetics of topiramate and carbamazepine in patients with epilepsy during monotherapy and concomitant therapy." Epilepsia 37 (1996): 774-80
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Topamax (topiramate)." Ortho Pharmaceutical Corporation, Raritan, NJ.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Bourgeois BF "Drug interaction profile of topiramate." Epilepsia 37(suppl 2 (1996): s14-7
Mack CJ, Kuc S, Mulcrone SA, Pilley A, Grunewald RA "Interaction of topiramate with carbamazepine: two case reports and a review of clinical experience." Seizure 11 (2002): 464-7

Qudexy XR

Generic Name: topiramate

Brand name: Qudexy XR Sprinkle, Topamax, Topamax Sprinkle, Trokendi XR, Qudexy XR, Topiragen

Synonyms: Qudexy XR Sprinkle, Qudexy XR Capsules

What is Qudexy XR?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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