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Quin-G and Rifampin Injection

Determining the interaction of Quin-G and Rifampin Injection and the possibility of their joint administration.

Check result:

Quin-G <> Rifampin Injection

Relevance: 23.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

RifAMPin may reduce the blood levels and effects of quiNIDine. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rifamycins may increase the hepatic metabolism of quinidine by inducing CYP450 3A4 isoenzymes. Serum quinidine levels and quinidine effect may be decreased.

MANAGEMENT: Frequent monitoring of quinidine levels and arrhythmia control is recommended. Increased quinidine dosage may be needed. When a rifamycin is discontinued, enzyme induction and increased hepatic metabolism of quinidine may persist for one week. Patients should be advised to notify their physician if they experience an increase in irregular heartbeats.

References

Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8
Reed R, Schwartz H "Phenytoin-theophylline-quinidine interactions." N Engl J Med 308 (1983): 724-5
Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Schwartz A, Brown JR "Quinidine-rifampin interaction." Am Heart J 107 (1984): 789-90
Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6
Bussey HI, Merritt GJ, Hill EG "The influence of rifampin on quinidine and digoxin." Arch Intern Med 144 (1984): 1021-3
Twum-Barima Y, Carruthers SG "Quinidine-rifampin interaction." N Engl J Med 304 (1981): 1466-9
Ahmad D, Mathur P, Ahuja S, Henderson R, Carruthers G "Rifampicin-quinidine interaction." Br J Dis Chest 73 (1979): 409-11

Quin-G

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quin-G?

Rifampin Injection

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: Rifampin

What is Rifampin Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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