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Quin-G and Verelan PM

Determining the interaction of Quin-G and Verelan PM and the possibility of their joint administration.

Check result:

Quin-G <> Verelan PM

Relevance: 23.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using quiNIDine together with verapamil may increase the effects of quiNIDine. Contact your doctor if you experience confusion, tiredness, seizures, difficulty breathing, fainting, and a rapid heartbeat. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Verapamil may increase plasma quinidine concentrations and elimination half-life by inhibiting CYP450 3A4 hepatic metabolism. While these drugs have frequently been given together safely, significant adverse side effects have been associated with the combination, especially in patients with hypertrophic or dilated cardiomyopathies and in patients on higher doses of either drug.

MANAGEMENT: If these drugs must be administered concurrently, clinical and electrocardiographic monitoring for quinidine toxicity (such as hypotension, arrhythmias, and AV block) is recommended. Lesser doses of quinidine are predicted to achieve a given plasma concentration and clinical response. Patients should be advised to notify their physician if they experience dizziness, blurry vision, diplopia, photophobia, vomiting, irregular heartbeats, tinnitus, hearing loss, headache, confusion, or delirium.

References

Edwards DJ, Lavoie R, Beckman H, et al "The effect of coadministration of verapamil on the pharmacokinetics and metabolism of quinidine." Clin Pharmacol Ther 41 (1987): 68-73
Trohman RG, Estes DM, Castellanos A, et al "Increased quinidine plasma concentrations during administration of verapamil: a new quinidine-verapamil interaction." Am J Cardiol 57 (1986): 706-7
Maisel AS, Motulsky HJ, Insel PA "Hypotension after quinidine plus verapamil." N Engl J Med 312 (1985): 167-70
Epstein SE, Rosing DR "Verapamil: its potential for causing serious complications in patients with hypertrophic cardiomyopathy." Circulation 64 (1981): 437-41
Dhein S, Schott M, Gottwald E, Klaus W "Electrocardiological profile and proarrhythmic effects of quinidine, verapamil and their combination: a mapping study." Naunyn Schmiedebergs Arch Pharmacol 352 (1995): 94-101
McTavish D, Sorkin EM "Verapamil: an updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension." Drugs 38 (1989): 19-76

Quin-G

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quin-G?

Verelan PM

Generic Name: verapamil

Brand name: Verelan PM, Calan, Calan SR, Isoptin SR, Verelan, Isoptin, Isoptin IV, Covera-HS

Synonyms: n.a.

What is Verelan PM?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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