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Quinidex Extentabs and Reyataz (Atazanavir Powder for Oral Suspension)

Determining the interaction of Quinidex Extentabs and Reyataz (Atazanavir Powder for Oral Suspension) and the possibility of their joint administration.

Check result:

Quinidex Extentabs <> Reyataz (Atazanavir Powder for Oral Suspension)

Relevance: 02.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using quiNIDine together with atazanavir can increase the effects of quiNIDine and may affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision or nausea. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with atazanavir may increase the plasma concentrations of amiodarone, systemic lidocaine, and quinidine. The proposed mechanism is atazanavir inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of these antiarrhythmic agents. The interaction has not been studied but could conceivably lead to serious and/or life-threatening reactions including cardiac arrhythmias and other toxicities.

MANAGEMENT: Caution is advised if atazanavir must be used with amiodarone, systemic lidocaine, or quinidine. Pharmacologic response and plasma antiarrhythmic drug levels should be monitored more closely whenever atazanavir is added to or withdrawn from therapy, and the antiarrhythmic dosage adjusted as necessary. According to some authorities, use of the fixed combination atazanavir-cobicistat with these antiarrhythmic agents is considered contraindicated.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Reyataz (atazanavir)." Bristol-Myers Squibb, Princeton, NJ.

Quinidex Extentabs

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quinidex Extentabs?

Reyataz (Atazanavir Powder for Oral Suspension)

Generic Name: atazanavir

Brand name: Reyataz

Synonyms: Reyataz

What is Reyataz (Atazanavir Powder for Oral Suspension)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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