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Quinidex Extentabs and Zantac Cool Mint

Determining the interaction of Quinidex Extentabs and Zantac Cool Mint and the possibility of their joint administration.

Check result:
Quinidex Extentabs <> Zantac Cool Mint
Relevance: 02.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using quiNIDine together with raNITIdine can increase the effects of quiNIDine. Contact your doctor if you experience ringing in the ears, hearing loss, visual disturbances, diarrhea, dizziness, weakness, headache, dizziness, or rapid or irregular heartbeats. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Cimetidine may increase serum quinidine levels and the risk of toxicity. The mechanism may be related to decreased CYP450 hepatic metabolism or competitive inhibition of renal excretion. A case of ventricular bigeminy has been reported with ranitidine coadministration, even though it is not expected to inhibit CYP450. No data are available for other H2-antagonists.

MANAGEMENT: If patients require cimetidine or ranitidine during quinidine therapy, monitoring for clinical and laboratory evidence of quinidine toxicity is recommended. Patients should be advised to notify their physician if they experience tinnitus, hearing loss, visual disturbances, diarrhea, dizziness, weakness, headache, syncope, or rapid or irregular heartbeats.

References
  • Farringer JA, McWay-Hess K, Clementi WA "Cimetidine-quinidine interaction." Clin Pharm 3 (1984): 81-3
  • Iliopoulou A, Kontogiannis D, Tsoutsos D, Moulopoulos S "Quinidine-ranitidine adverse reaction." Eur Heart J 7 (1986): 360
  • Kolb KW, Garnett WR, Small RE, Vetrovec GW, Kline BJ, Fox T "Effect of cimetidine on quinidine clearance." Ther Drug Monit 6 (1984): 306-12
  • Hardy BG, Istvan ZT, Golden L, Lalka D, Schentag JJ "Effect of cimetidine on the pharmacokinetics pharmacodynamics of quinidine." Am J Cardiol 52 (1983): 172-5
Quinidex Extentabs

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

Zantac Cool Mint

Generic Name: ranitidine

Brand name: Zantac

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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Disease interaction