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Quinidex Extentabs and Zebutal

Determining the interaction of Quinidex Extentabs and Zebutal and the possibility of their joint administration.

Check result:

Quinidex Extentabs <> Zebutal

Relevance: 02.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using quiNIDine together with butalbital can decrease the levels of quiNIDine. The levels of quiNIDine in your blood may need to be evaluated when butalbital is started or stopped. You may need a dose adjustment or special tests to safely use both medications. Contact your doctor if you notice worsening irregular heartbeats, chest pain, dizziness or other symptoms. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Some barbiturates may significantly decrease serum quinidine concentrations and half-life. The mechanism is induction of CYP450 3A4 hepatic metabolism of quinidine. Data are available for pentobarbital, phenobarbital, and primidone.

MANAGEMENT: Monitor the effectiveness and serum levels of quinidine until a stable, safe, and therapeutic level is achieved after a barbiturate is added or deleted from this patient's regimen. Dose adjustments may be required. Patients should be advised to notify their physician if they experience worsening irregular heartbeats or exacerbation of other symptoms. Patients should also be observed for quinidine toxicity after the barbiturate is discontinued.

References

Kroboth FJ, Kroboth PD, Logan T "Phenytoin-theophylline-quinidine interaction." N Engl J Med 308 (1983): 725
Rodgers GC, Blackman MS "Quinidine interaction with anticonvulsants." Drug Intell Clin Pharm 17 (1983): 819-20
Data JL, Wilkinson GR, Nies AS "Interaction of quinidine with anticonvulsant drugs." N Engl J Med 294 (1976): 699-702

Quinidex Extentabs

Generic Name: quinidine

Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release

Synonyms: n.a.

What is Quinidex Extentabs?

Zebutal

Generic Name: acetaminophen / butalbital / caffeine

Brand name: Capacet, Esgic, Fioricet, Margesic, Medigesic, Orbivan, Repan, Vanatol LQ, Zebutal, Esgic-Plus, Arcet, Isocet, Pharmagesic, Anoquan, Two-Dyne, Tenake, Anolor 300, Femcet, Geone, Tencet, Triad, Fiorpap, Dolmar, Endolor, Ezol, Ide-cet, G-1, Minotal, Mygracet, Pacaps, Alagesic, Americet, Nonbac, Dolgic LQ, Dolgic Plus, Vanatol S, Alagesic LQ

Synonyms: n.a.

What is Zebutal?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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