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Quinine and Seconal Sodium

Determining the interaction of Quinine and Seconal Sodium and the possibility of their joint administration.

Check result:

Quinine <> Seconal Sodium

Relevance: 21.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using quiNINE together with secobarbital. Combining these medications may reduce the blood levels and effects of quiNINE. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of quinine, which is primarily metabolized by the isoenzyme. The interaction has been studied with rifampin, a potent CYP450 3A4 inducer, and treatment failures have been reported. In patients with uncomplicated Plasmodium falciparum malaria who received quinine sulfate 10 mg/kg concomitantly with rifampin 15 mg/kg/day for 7 days, the median quinine systemic exposure (AUC) between days 3 and 7 of therapy was 75% lower than that observed in patients who received quinine monotherapy. Likewise, in nine healthy subjects who received a single 600 mg oral dose of quinine sulfate following pretreatment with rifampin 600 mg/day for 2 weeks, the mean quinine peak plasma concentration (Cmax) and AUC decreased by 55% and 85%, respectively. The extent to which other, less potent inducers of CYP450 3A4 may interact with quinine is unknown.

MANAGEMENT: Caution is advised if quinine is used in combination with CYP450 3A4 inducers such as carbamazepine, phenobarbital, phenytoin, and St. John's wort. The possibility of diminished therapeutic efficacy should be considered. rifampin

References

Fabre C, Criddle J, Nolder D, Klein JL "Recrudescence of imported falciparum malaria after quinine therapy: potential drug interaction with phenytoin." Trans R Soc Trop Med Hyg 99 (2005): 871-3
"Product Information. Qualaquin (quinine)." AR Scientific Inc, Philadelphia, PA.
"Product Information. Rifadin (rifampin)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Pukrittayakamee S, Prakongpan S, Wanwimolruk S, Clemens R, Looareesuwan S, White NJ "Adverse effect of rifampin on quinine efficacy in uncomplicated falciparum malaria." Antimicrob Agents Chemother 47 (2003): 1509-1513
Twum-Barima Y, Carruthers SG "Quinidine-rifampin interaction." N Engl J Med 304 (1981): 1466-9
Wanwimolruk S, Kang W, Coville PF, Viriyayudhakorn S, Thitiarchakul S "Marked enhancement by rifampicin and lack of effect of isoniazid on the elimination of quinine in man." Br J Clin Pharmacol 40 (1995): 87-91

Quinine

Generic Name: quinine

Brand name: Qualaquin, QM-260, Quinamm

Synonyms: QuiNINE

What is Quinine?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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