Quinupristin and Dalfopristin and Zarontin (Ethosuximide Solution)
Determining the interaction of Quinupristin and Dalfopristin and Zarontin (Ethosuximide Solution) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dalfopristin may increase the blood levels and effects of ethosuximide. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Based on in vitro inhibition data, coadministration with dalfopristin-quinupristin may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by dalfopristin-quinupristin.
MANAGEMENT: Caution is advised if dalfopristin-quinupristin must be used concurrently with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever dalfopristin-quinupristin is added to or withdrawn from therapy.
- "Product Information. Synercid (dalfopristin-quinupristin)" Rhone-Poulenc Rorer, Collegeville, PA.
Generic Name: dalfopristin / quinupristin
Brand name: Synercid
Synonyms: Dalfopristin and quinupristin
Generic Name: ethosuximide
Brand name: Zarontin
Synonyms: Zarontin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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