Rabeprazole Sodium and Trastuzumab-dkst Intravenous

• Generic Name: rabeprazole
• Dosage Forms: n.a.
• Other Brand Names: Aciphex, AcipHex Sprinkle

Short-term treatment of symptomatic GERD (e.g., heartburn) in patients without erosive esophagitis.

Short-term treatment of erosive esophagitis in patients with GERD.

Maintain healing and decrease recurrence of erosive esophagitis.

Short-term treatment of active duodenal ulcer.

Treatment of Helicobacter pylori infection and duodenal ulcer disease. Used in conjunction with amoxicillin and clarithromycin (triple therapy).

Long-term treatment of pathologic GI hypersecretory conditions (e.g., Zollinger-Ellison syndrome).

Some evidence for use of proton-pump inhibitors (e.g., omeprazole) for gastric acid suppressive therapy as an adjunct in the management of upper GI Crohn’s disease, including esophageal, gastroduodenal, and jejunoileal disease.

• Generic Name: trastuzumab
• Dosage Forms: n.a.
• Other Brand Names: Herceptin, Kanjinti, Ogivri

Trastuzumab-dkst injection is used alone or together with other cancer medicines (eg, carboplatin, cyclophosphamide, docetaxel, doxorubicin, paclitaxel) to treat HER2-overexpressing new or metastatic (cancer that has spread) breast cancer.

Trastuzumab-dkst injection is also used in combination with cisplatin and capecitabine or 5-fluorouracil to treat HER2-overexpressing metastatic (cancer that has spread) stomach and gastroesophageal (stomach and esophagus) cancer.

Trastuzumab-dkst prevents the growth of some tumors that produce extra amounts of a certain substance known as the HER2 protein. It should only be used in patients whose tumors have been shown to produce extra amounts of this protein (HER2 overexpression).

Trastuzumab-dkst is a monoclonal antibody. It interferes with the growth of cancer cells, which are eventually destroyed by the body. Since the growth of normal body cells may also be affected by trastuzumab-dkst, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, such as a skin rash, may not be serious but may cause concern. Some effects do not occur until months or years after the medicine is used.

Trastuzumab-dkst is to be given only by or under the immediate supervision of your doctor.