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Radium ra 223 dichloride Intravenous and Zytiga

Determining the interaction of Radium ra 223 dichloride Intravenous and Zytiga and the possibility of their joint administration.

Check result:

Radium ra 223 dichloride Intravenous <> Zytiga

Relevance: 03.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using abiraterone together with radium Ra 223 dichloride is not recommended. Combining these medications may have harmful effects and can increase the risk of bone fractures and even death. If you are currently being treated with this combination, your doctor will alter your treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: The concomitant use of radium Ra 223 dichloride with abiraterone and prednisone/prednisolone may increase the risk of death and fractures in patients with metastatic castration-resistant prostate cancer (CRPC). Preliminary results of a phase III clinical trial involving this combination has reported an increased risk of mortality (34.7% vs 28.2%) and fractures (26% vs 8.1%) in patients receiving radium Ra 223 dichloride plus abiraterone and prednisone/prednisolone compared to patients treated with placebo and abiraterone and prednisone/prednisolone (n=405). It is unknown if enzalutamide (a second generation androgen receptor antagonist) can be effectively and safely used with radium Ra 223 dichloride.

MANAGEMENT: Until more information is available, use of radium Ra 223 dichloride with abiraterone and prednisone/prednisolone should be considered contraindicated. US authorities are prohibiting the start of new treatments with this combination and suspending use in patients currently receiving these drugs in combination in favor of other therapeutic alternatives. Some authorities recommend that subsequent treatment with radium Ra 223 dichloride should not be initiated for at least 5 days after the last administration of abiraterone in combination with prednisone/prednisolone (AU, UK, EU). In addition, continued monitoring for fractures should be considered for patients previously treated with the combination. Preliminary evidence suggests that use of bone health agents such as bisphosphonates or denosumab may diminish the risk of fractures.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
Bayer HealthCare Pharmaceuticals, Inc "Important Drug Warning: Xofigo. Available from: URL: https://hcp.xofigo-us.com/downloads/pdf/PP-600-US-3282%20Xofigo%20November%202017%20DHCP%20Letter%20-%20Digital%20Version.pdf." ([2017, Nov 30]):
European Medicines Agency "Prostate cancer medicine Xofigo must not be used with Zytiga and prednisone/prednisolone. Available from: URL: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Xofigo_20/Under_evaluation/WC500245467.pdf." ([2018, Mar 19]):
EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000366.jsp&mid=WC0b01ac058067c852" ([2013 - ]):

Radium ra 223 dichloride Intravenous

Generic Name: radium 223 dichloride

Brand name: Xofigo

Synonyms: Radium Ra 223 Dichloride

What is Radium ra 223 dichloride Intravenous?

Zytiga

Generic Name: abiraterone

Brand name: Yonsa, Zytiga

Synonyms: n.a.

What is Zytiga?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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