Raltegravir Potassium and Tipranavir Oral Solution
Determining the interaction of Raltegravir Potassium and Tipranavir Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with tipranavir/ritonavir may reduce the plasma concentrations of raltegravir. The proposed mechanism is induction of raltegravir glucuronidation via uridine diphosphate glucuronosyltransferase (UGT) 1A1. In 15 study subjects, administration of raltegravir 400 mg twice daily in combination with tipranavir/ritonavir 500 mg/200 mg twice daily decreased the raltegravir peak plasma concentration (Cmax), systemic exposure (AUC), and trough plasma concentration (Cmin) by 18%, 24%, and 55%, respectively. The long-term clinical significance of these changes, particularly the reduction in Cmin, is uncertain. In two clinical trials, comparable efficacy was observed in approximately 100 subjects who received raltegravir in combination with tipranavir/ritonavir relative to subjects who did not receive tipranavir/ritonavir. Based on these data, no dosage adjustment of raltegravir is necessary when used together with tipranavir/ritonavir.
- "Product Information. Isentress (raltegravir)." Merck & Company Inc, West Point, PA.
- "Product Information. Aptivus (tipranavir)." Boehringer-Ingelheim, Ridgefield, CT.
Generic Name: raltegravir
Brand name: Isentress, Isentress HD
Synonyms: Raltegravir
Generic Name: tipranavir
Brand name: Aptivus
Synonyms: Tipranavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Raltegravir Potassium-Tirofiban
- Raltegravir Potassium-Tirofiban Intravenous
- Raltegravir Potassium-Tirosint
- Raltegravir Potassium-Tirosint-Sol
- Raltegravir Potassium-Tisagenlecleucel
- Raltegravir Potassium-Tisagenlecleucel Intravenous
- Tipranavir Oral Solution-Raltegravir Powder for Oral Suspension
- Tipranavir Oral Solution-Raltegravir Tablets
- Tipranavir Oral Solution-Ramelteon
- Tipranavir Oral Solution-Ramelteon Tablets
- Tipranavir Oral Solution-Ramipril
- Tipranavir Oral Solution-Ramipril Tablets