Rapamune and Talazoparib

• Generic Name: sirolimus
• Dosage Forms: oral solution, tablets
• Other Brand Names: Rapamune

Rapamune weakens your body's immune system, to help keep it from "rejecting" a transplanted organ such as a kidney. Organ rejection happens when the immune system treats the new organ as an invader and attacks it.

Rapamune is used with other medicines to prevent organ rejection after a kidney transplant.

Rapamune is also given without other medicines to treat a rare lung disorder called lymphangioleiomyomatosis (lim-FAN-gee-oh-LYE-oh-MYE-oh-ma-TOE-sis). This disorder happens mostly in women and causes lung tumors that are not cancerous but can affect breathing.

Rapamune may also be used for purposes not listed in this medication guide.

• Generic Name: talazoparib
• Dosage Forms: n.a.
• Other Brand Names: Talzenna

Talazoparib is used to treat HER2-negative breast cancer that has spread to other parts of the body.

Talazoparib is used only if your cancer has a specific genetic marker (an abnormal "BRCA" gene). Your doctor will test you for this gene.

Talazoparib may also be used for purposes not listed in this medication guide.