Rapamune (Sirolimus Oral Solution) and Sorafenib
Determining the interaction of Rapamune (Sirolimus Oral Solution) and Sorafenib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:SORAfenib may increase the blood levels and effects of sirolimus. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Based on in vitro inhibition data, coadministration with sorafenib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, liver, and/or kidney due to inhibition of P-glycoprotein-mediated drug efflux by sorafenib.
MANAGEMENT: Caution is advised when sorafenib is used concurrently with drugs that are known P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever sorafenib is added to or withdrawn from therapy.
- "Product Information. Nexavar (sorafenib)." Bayer Pharmaceutical Inc, West Haven, CT.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: sirolimus
Brand name: Rapamune
Synonyms: Rapamune
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Rapamune (Sirolimus Oral Solution)-Sorafenib Tosylate
- Rapamune (Sirolimus Oral Solution)-Sorbitol
- Rapamune (Sirolimus Oral Solution)-Sorbitol Irrigation Solution
- Rapamune (Sirolimus Oral Solution)-Sorbitol Solution
- Rapamune (Sirolimus Oral Solution)-Sorbitol-Mannitol
- Rapamune (Sirolimus Oral Solution)-Soriatane
- Sorafenib-Rapamune (Sirolimus Tablets)
- Sorafenib-Rapamune Tablets
- Sorafenib-Rapiflux
- Sorafenib-Rapivab
- Sorafenib-Raptiva
- Sorafenib-Rasagiline