Rapamune (Sirolimus Oral Solution) and Vfend

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using sirolimus and voriconazole is not recommended. Taking these drugs together can this can increase the blood levels or add to the side effects of sirolimus, and cause symptoms such as nausea, fever, tiredness, abdominal pain, or jaundice (yellowing of the skin or eyes). Talk to your doctor if you have any concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with voriconazole may significantly increase the plasma concentrations of sirolimus. The mechanism is voriconazole inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of sirolimus. According to the manufacturer, voriconazole (400 mg orally every 12 hours for 1 day, then 200 mg every 12 hours for 8 days) increased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of sirolimus (2 mg single dose) by an average of 7- and 11-fold, respectively, in healthy subjects.

MANAGEMENT: The use of sirolimus with voriconazole is considered contraindicated.

Rapamune (Sirolimus Oral Solution)

Generic Name: sirolimus

Brand name: Rapamune

Synonyms: Rapamune

What is Rapamune (Sirolimus Oral Solution)?

Vfend

Generic Name: voriconazole

Brand name: Vfend, Vfend

Synonyms: Vfend Injection

What is Vfend?