Rapamune (Sirolimus Tablets) and Solurex LA injection
Determining the interaction of Rapamune (Sirolimus Tablets) and Solurex LA injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Dexamethasone may reduce the blood levels of sirolimus in some patients, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of sirolimus and tacrolimus, both of which are primarily metabolized by the isoenzyme.
MANAGEMENT: Given the risk of organ rejection associated with inadequate immunosuppressant drug levels, caution is advised during concomitant therapy with CYP450 3A4 inducers. Sirolimus and tacrolimus blood levels should be checked frequently and the dosage adjusted accordingly whenever a CYP450 3A4 inducer is added to or withdrawn from therapy.
- "Product Information. Prograf (tacrolimus)." Fujisawa, Deerfield, IL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Rapamune (sirolimus)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
Generic Name: sirolimus
Brand name: Rapamune
Synonyms: Rapamune
Generic Name: dexamethasone
Brand name: De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, Decadron, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort
Synonyms: Solurex LA (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Rapamune (Sirolimus Tablets)-Soma
- Rapamune (Sirolimus Tablets)-Soma Compound
- Rapamune (Sirolimus Tablets)-Soma Compound with Codeine
- Rapamune (Sirolimus Tablets)-Somatropin
- Rapamune (Sirolimus Tablets)-Somatropin (rDNA origin - Nonrefrigerated) (SBS)
- Rapamune (Sirolimus Tablets)-Somatropin (rDNA origin)
- Solurex LA injection-Rapamune Tablets
- Solurex LA injection-Rapiflux
- Solurex LA injection-Rapivab
- Solurex LA injection-Raptiva
- Solurex LA injection-Rasagiline
- Solurex LA injection-Rasagiline Mesylate