Drug search by name

Rebetol (Ribavirin Oral Solution) and Retrovir

Determining the interaction of Rebetol (Ribavirin Oral Solution) and Retrovir and the possibility of their joint administration.

Check result:

Rebetol (Ribavirin Oral Solution) <> Retrovir

Relevance: 19.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using zidovudine together with ribavirin. You should contact your doctor if you experience symptoms of toxicity such as nausea, vomiting, abdominal pain/distention, fatigue, infection, unexplained weight loss, shortness of breath, motor weakness, numbness, tingling, and pain in hands and feet. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Ribavirin, a nucleoside analog, has been shown to antagonize the in vitro antiviral activity of zidovudine against HIV. The mechanism is feedback inhibition of thymidine kinase induced by ribavirin, resulting in decreased intracellular phosphorylation of zidovudine to its active triphosphate metabolite. The clinical relevance of this finding is unknown. Preliminary data from a small number of HCV-HIV coinfected patients receiving interferon-ribavirin therapy and different antiretroviral regimens containing zidovudine do not support a major clinical impact related to the in vitro effect. However, the potential for diminished antiretroviral activity should be considered, as three patients in one study had an increase in HIV viral load of more than 0.5 log after 3 to 6 months of interferon-ribavirin therapy which led to discontinuation of ribavirin in one. In addition, the risk of myelosuppression and mitochondrial toxicities such as lipodystrophy, peripheral neuropathy, pancreatitis, and lactic acidosis associated with nucleoside reverse transcriptase inhibitors may be increased during coadministration with ribavirin. Nucleoside analogs alone and in combination have been associated with these and other toxicities.

MANAGEMENT: Coadministration of ribavirin with zidovudine should generally be avoided. Patients should be advised to promptly seek medical attention if they experience symptoms of toxicity such as nausea, vomiting, abdominal pain/distention, fatigue, infection, unexplained weight loss, tachypnea, dyspnea, motor weakness, numbness, tingling, and pain in hands and feet. Dosage reduction or discontinuation of ribavirin should be considered if worsening toxicities are observed.

References

Vogt MW, Hartshorn KL, Furman PA, et al. "Ribavirin antagonizes the effect of azidothymidine on HIV replication." Science 235 (1987): 1376-9
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
Hoggard PG, Veal GJ, Wild MJ, Barry MG, Back DJ "Drug interactions with zidovudine phosphorylation in vitro." Antimicrob Agents Chemother 39 (1995): 1376-8
"Product Information. Copegus (ribavirin)." Roche Laboratories, Nutley, NJ.
Guyader D, Poinsignon Y, Cano Y, Saout L "Fatal lactic acidosis in a HIV-positive patient treated with interferon and ribavirin for chronic hepatitis C." J Hepatol 37 (2002): 289-91
"Product Information. Retrovir (zidovudine)." Glaxo Wellcome, Research Triangle Park, NC.
Taburet AM, Singlas E "Drug interactions with antiviral drugs." Clin Pharmacokinet 30 (1996): 385-401
Landau A, Batisse D, Piketty C, Jian R, Kazatchkine MD "Lack of interference between ribavirin and nucleosidic analogues in HIV/HCV co-infected individuals undergoing concomitant antiretroviral and anti-HCV combination therapy." AIDS 14 (2000): 1857-8
Zylberberg H, Benhamou Y, Lagneaux JL, et al "Safety and efficacy of interferon-ribavirin combination therapy in HCV-HIV coinfected subjects: an early report." Gut 47 (2000): 694-7
Lafeuillade A, Hittinger G, Chadapaud S "Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection." Lancet 357 (2001): 280-1
Hoggard PG, Kewn S, Barry MG, Khoo SH, Back DJ "Effects of drugs on 2',3'-didehydrothymidine phosphorylation in vitro." Antimicrob Agents Chemother 41 (1997): 1231-6

Rebetol (Ribavirin Oral Solution)

Generic Name: ribavirin

Brand name: Rebetol, RibaPak, Ribasphere, RibaTab, Copegus, Virazole, RibaPak 600, Moderiba, Moderiba 800 Dose Pack, Moderiba 1200 Dose Pack, Moderiba 1000 Dose Pack, Moderiba 600 Dose Pack

Synonyms: Rebetol

What is Rebetol (Ribavirin Oral Solution)?

Retrovir

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Retrovir (oral/injection)

What is Retrovir?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions