Rectiv topical and Siltuximab

• Generic Name: nitroglycerin
• Dosage Forms: rectal ointment
• Other Brand Names: Rectiv, Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit

Intra-anal treatment of moderate to severe pain associated with chronic anal fissure.

Chronic anal fissure is thought to be related to sustained high resting anal sphincter tone and associated anodermal ischemia. Lateral internal sphincterotomy generally has been used to treat anal fissures that do not respond to conservative therapy (e.g., sitz baths, increased dietary fiber); however, minor incontinence, which may be persistent, may develop after surgery. Botulinum toxin type A injections or topical therapy with nitrates (e.g., nitroglycerin rectal ointment) or calcium-channel blocking agents (e.g., diltiazem gel, not commercially available in US) has been used to reduce anal sphincter tone and circumvent potential complications of surgery.

• Generic Name: siltuximab
• Dosage Forms: n.a.
• Other Brand Names: Sylvant

Siltuximab is used to treat Multicentric Castleman's Disease (MCD). MCD is a rare condition in which the body produces too much of a certain type of white blood cell. MCD can increase your risk of certain cancers by changing the way your immune system works.

Siltuximab is not for use in people who have human immunodeficiency virus (HIV) or human herpesvirus-8.

Siltuximab may also be used for purposes not listed in this medication guide.