Rectiv topical and Xeljanz XR

• Generic Name: nitroglycerin
• Dosage Forms: rectal ointment
• Other Brand Names: Rectiv, Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit

Intra-anal treatment of moderate to severe pain associated with chronic anal fissure.

Chronic anal fissure is thought to be related to sustained high resting anal sphincter tone and associated anodermal ischemia. Lateral internal sphincterotomy generally has been used to treat anal fissures that do not respond to conservative therapy (e.g., sitz baths, increased dietary fiber); however, minor incontinence, which may be persistent, may develop after surgery. Botulinum toxin type A injections or topical therapy with nitrates (e.g., nitroglycerin rectal ointment) or calcium-channel blocking agents (e.g., diltiazem gel, not commercially available in US) has been used to reduce anal sphincter tone and circumvent potential complications of surgery.

• Generic Name: tofacitinib
• Dosage Forms: n.a.
• Other Brand Names: Xeljanz, Xeljanz XR

Xeljanz XR is used to treat moderate to severe rheumatoid arthritis or active psoriatic arthritis in adults who have tried methotrexate or other medications without successful treatment of symptoms. This medicine is sometimes given in combination with methotrexate or other arthritis medicines.

Xeljanz XR is also used to treat moderate to severe ulcerative colitis in adults who cannot use certain other medications, or after other treatments have failed. Extended-release this medicine (Xeljanz XR) is not for use in treating ulcerative colitis.

Xeljanz XR may also be used for purposes not listed in this medication guide.