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Red yeast rice and Rescriptor

Determining the interaction of Red yeast rice and Rescriptor and the possibility of their joint administration.

Check result:

Red yeast rice <> Rescriptor

Relevance: 14.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using red yeast rice together with delavirdine. Using these medications together can increase your blood levels of red yeast rice and may cause a dangerous side effect on your muscles. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. You should also watch for muscle symptoms and call the doctor if you have muscle pain, tenderness, or weakness, especially if you also have dark colored urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Delavirdine may significantly elevate the plasma concentrations of HMG-CoA reductase inhibitors. The mechanism is decreased clearance due to inhibition of CYP450 3A4 metabolism by delavirdine. Myopathy manifested as muscle pain and/or weakness associated with grossly elevated creatine kinase has been reported occasionally with the use of HMG-CoA reductase inhibitors. Rhabdomyolysis has also occurred rarely, which may be accompanied by acute renal failure secondary to myoglobinuria.

MANAGEMENT: Because of the increased risk of musculoskeletal toxicity associated with high levels of HMG-CoA reductase inhibitory activity in plasma, concurrent use is not recommended by the manufacturer. If patients do receive this combination, they should be closely monitored for early signs of myopathy and advised to report symptoms of muscular pain, weakness, tenderness, malaise, or fever. Pravastatin may be a safer alternative, since it is metabolized by a different pathway.

References

"Product Information. Rescriptor (delavirdine)." Pharmacia and Upjohn, Kalamazoo, MI.

Red yeast rice

Generic Name: red yeast rice

Brand name: Cholestin

Synonyms: Red Yeast Rice

What is Red yeast rice?

Rescriptor

Generic Name: delavirdine

Brand name: Rescriptor

Synonyms: n.a.

What is Rescriptor?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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