Remodulin injection and Rifadin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

RifAMPin may reduce the blood levels and effects of treprostinil. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inducers of CYP450 2C8 may decrease the plasma concentrations of treprostinil, which is primarily metabolized by the isoenzyme. Human pharmacokinetic studies with an oral formulation of treprostinil indicate that concomitant administration of the CYP450 2C8 inducer rifampin decreases exposure (both Cmax and AUC) to treprostinil. However, it has not been determined if the safety and efficacy of treprostinil administered subcutaneously or intravenously are altered by this interaction.

MANAGEMENT: Pharmacologic response to treprostinil should be monitored more closely whenever a CYP450 2C8 inducer is added to or withdrawn from therapy, and the treprostinil dosage adjusted as necessary. Patients should be advised to notify their physician if they experience worsening of their condition.

Remodulin injection

Generic Name: treprostinil

Brand name: Remodulin, Orenitram, Tyvaso, Tyvaso Refill Kit, Tyvaso Starter Kit

Synonyms: Remodulin (injection), Remodulin

What is Remodulin injection?

Rifadin

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rifadin?