Renflexis and Tice BCG Live (for intravesical use)
Determining the interaction of Renflexis and Tice BCG Live (for intravesical use) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:If you are currently being treated or have recently been treated with inFLIXimab, you should let your doctor know before receiving BCG. Depending on the dose and length of time you have been on inFLIXimab, you may be at risk for developing an infection from BCG or have a reduced response to BCG. In some situations, your doctor may want to delay treatment with BCG to give your body time to recover from the effects of inFLIXimab therapy. Additionally, since the bacteria in BCG may persist in the urinary tract for months after treatment, you may still be at increased risk for infection even if you receive inFLIXimab after you have stopped treatment with BCG for some time. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:CONTRAINDICATED: Administration of intravesical BCG during immunosuppressant or intense antineoplastic therapy may be associated with a risk of disseminated infection due to enhanced replication of the BCG strain of Mycobacterium bovis in the presence of diminished immune competence. Deaths have been reported as a result of systemic BCG infection and sepsis. Patients may be immunosuppressed if they have recently received or are receiving alkylating agents, antimetabolites, radiation, some antirheumatic agents, high dosages of corticosteroids or adrenocorticotropic agents (e.g., greater than 10 mg/day or 1 mg/kg/day of prednisone or equivalent for more than 2 weeks), or long-term topical or inhaled corticosteroids. In addition, these patients may not develop an adequate immune response to BCG, which would reduce its anti-tumor efficacy.
MANAGEMENT: Use of intravesical BCG in immunosuppressed patients with congenital or acquired immune deficiencies, including those due to concurrent disease (e.g., AIDS, leukemia, lymphoma), cancer therapy (e.g., cytotoxic drugs, radiation) or immunosuppressive therapy (e.g., corticosteroids), is considered contraindicated. Clinicians should be aware that BCG may persist in the urinary tract for several months after BCG instillations, and delayed manifestations of disseminated BCG infection may develop months or years after BCG therapy. Patients who receive cancer or immunosuppressive therapy after BCG instillation may be at increased risk.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Rawls WH, Lamm DL, Lowe BA, et al. "Fatal sepsis following intravesical bacillus Calmette-Guerin administration for bladder cancer." J Urol 144 (1990): 1328-30
- Lamm DL, Stogdill VD, Stogdill BJ, Crispen RG "Complications of bacillus Calmette-Guerin immunotherapy in 1,278 patients with bladder cancer." J Urol 135 (1986): 272-4
- "Product Information. Tice BCG Live (for intravesical use) (BCG)." Organon Pharmaceuticals, West Orange, NJ.
Generic Name: infliximab
Brand name: Inflectra, Remicade, Renflexis
Synonyms: n.a.
Generic Name: bcg
Brand name: Tice BCG Live, Tice BCG Vaccine, Theracys 3, TheraCys, BCG vaccine, Tice BCG
Synonyms: BCG intravesical, BCG (Intravesical)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Renflexis-Ticlid
- Renflexis-Ticlopidine
- Renflexis-Ticlopidine Hydrochloride
- Renflexis-Ticon
- Renflexis-Ticon oral/injection
- Renflexis-Tigan
- Tice BCG Live (for intravesical use)-Renflexis Intravenous
- Tice BCG Live (for intravesical use)-Reno Capsules
- Tice BCG Live (for intravesical use)-Reno-30
- Tice BCG Live (for intravesical use)-Reno-60
- Tice BCG Live (for intravesical use)-Reno-Dip
- Tice BCG Live (for intravesical use)-RenoCal-76