Renovo Patch and Trandolapril

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Concomitant use of ACE inhibitors and capsaicinoid topical products may potentiate the cough associated with these agents individually. In 16 healthy volunteers, pretreatment with oral captopril (25 mg) two hours before inhalation of nebulized incremental doses of capsaicin (0.5 to 20 micromol/L in normal saline) resulted in a significant shift of the dose-response curve to capsaicin compared to pretreatment with placebo. The geometric mean dose of capsaicin causing 20 coughs per minute was 1.3 micromol/L for captopril and 2.8 micromol/L for placebo. In a case report, a 53-year-old woman who had been treated with an ACE inhibitor for several years complained of cough each time she applied a 0.075% capsaicin cream to her lower extremities. The patient had not experienced a cough during treatment with the ACE inhibitor alone. However, capsaicin alone may also induce coughing.

Renovo Patch

Generic Name: capsaicin / menthol topical

Brand name: Aflexeryl-MC, Alivio, Capsiderm, Captracin, Icy Hot PM, Provenza, Puroxcin, Reciphexamine, Relyyks, Synvexia, Terocin, Zeruvia

Synonyms: Renovo

What is Renovo Patch?

Trandolapril

Generic Name: trandolapril

Brand name: Mavik

Synonyms: n.a.

What is Trandolapril?