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Rescula and Travatan Z

Determining the interaction of Rescula and Travatan Z and the possibility of their joint administration.

Check result:

Rescula <> Travatan Z

Relevance: 22.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using unoprostone ophthalmic together with travoprost ophthalmic may reduce the pressure-lowering effects of these medications in the eye. Talk to your doctor if you have any questions or concerns. You may need more frequent eye examinations to safely use these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Concurrent use of multiple prostaglandin analogs, as well as more frequent administration of a prostaglandin analog than recommended, may reduce the intraocular pressure (IOP) lowering effects of these agents. A case series of 3 patients described IOP elevations of 6 to 23 mmHg two to five weeks after bimatoprost was added to a latanoprost regimen. The precise mechanism of interaction has not been established, although the combination exceeded the dose-response curve, which may have led to the paradoxical effects on IOP. Other factors such as disease state and patient compliance may also have contributed. In a randomized clinical trial of 18 patients with non-advanced primary open angle glaucoma, mean IOP increased by 1.8 mmHg four weeks after the addition of bimatoprost to preexisting latanoprost treatment, but returned to baseline after discontinuation of bimatoprost.

MANAGEMENT: Concomitant administration of two or more prostaglandin analogs, or more frequent administration of a prostaglandin analog than approved by the manufacturers, is generally not recommended.

References

Doi LM, Melo LA, Prata JA "Effects of the combination of bimatoprost and latanoprost on intraocular pressure in primary open angle glaucoma: a randomized clinical trial." Br J Ophthalmol 89 (2005): 547-9
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Herndon LW, Asrani SG, Williams GH, Challa P, Lee PP "Paradoxical intraocular pressure elevation after combined therapy with latanoprost and bimatoprost." Arch Ophthalmol 120 (2002): 847-9
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Xalatan (latanoprost ophthalmic)." Pharmacia and Upjohn, Kalamazoo, MI.

Rescula

Generic Name: unoprostone ophthalmic

Brand name: Rescula

Synonyms: Rescula Ophthalmic Solution

What is Rescula?

Travatan Z

Generic Name: travoprost ophthalmic

Brand name: Travatan, Travatan Z

Synonyms: Travatan Z Ophthalmic Solution

What is Travatan Z?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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