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Retrovir and Zerit

Determining the interaction of Retrovir and Zerit and the possibility of their joint administration.

Check result:

Retrovir <> Zerit

Relevance: 09.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using zidovudine together with stavudine. Using these medications together may cause either medication to be less effective. Contact your doctor if your condition worsens. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: In vitro data have demonstrated an antagonistic relationship between zidovudine and stavudine. The proposed mechanism is competition for phosphorylating enzymes required for nucleoside activation. A 41% reduction in active stavudine metabolites was reported when zidovudine was administered with stavudine. No effect on zidovudine activity was noted. Reduced stavudine activation and loss of antiviral activity due to prior zidovudine modification of intracellular phosphorylation has been suggested, but this was not confirmed by other studies. Further clarification is needed.

MANAGEMENT: The manufacturer recommends against concurrent use.

References

"Product Information. Retrovir (zidovudine)." Glaxo Wellcome, Research Triangle Park, NC.
Hoggard PG, Barry MG, Khoo SH, Back DJ "Drug interactions with d4T phosphorylation in vitro." Br J Clin Pharmacol 42 (1996): 278P
Hoggard PG, Kewn S, Barry MG, Khoo SH, Back DJ "Effects of drugs on 2',3'-didehydrothymidine phosphorylation in vitro." Antimicrob Agents Chemother 41 (1997): 1231-6
Havlir DV, Tierney C, Friedland GH, Pollard RB, Smeaton L, Sommadossi JP, Fox L, Kessler H, Fife KH, Richman DD "In vivo antagonism with zidovudine plus stavudine combination therapy." J Infec Dis 182 (2000): 321-5
Hoggard PG, Veal GJ, Wild MJ, Barry MG, Back DJ "Drug interactions with zidovudine phosphorylation in vitro." Antimicrob Agents Chemother 39 (1995): 1376-8
Barry M, Mulcahy F, Merry C, Gibbons S, Back D "Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection." Clin Pharmacokinet 36 (1999): 289-304
Merrill DP, Moonis M, Chou TC, Hirsch MS "Lamivudine or stavudine in two- and three-drug combinations against human immunodeficiency virus type 1 replication in vitro." J Infect Dis 173 (1996): 355-64

Retrovir

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Retrovir (oral/injection)

What is Retrovir?

Zerit

Generic Name: stavudine

Brand name: Zerit, Zerit XR

Synonyms: n.a.

What is Zerit?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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