Retrovir (Zidovudine Capsules and Tablets) and Septra

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Limited data indicate that zidovudine may significantly increase the serum half-life of both trimethoprim (TMP) and sulfamethoxazole (SMX). The mechanism is not known, but may be related to an increase in the volume of distribution of each drug. In addition, trimethoprim can decrease the renal clearance of zidovudine and its glucuronide metabolite by inhibiting their tubular secretion. However, net clearance is not affected because zidovudine is mostly metabolized and the glucuronide may be eliminated via biliary excretion. This interaction is not likely to be clinically important except when hepatic glucuronidation is also impaired by liver disease or drug inhibition.
Recommended management consists of monitoring for side effects of each drug and reducing dosages as necessary.

Retrovir (Zidovudine Capsules and Tablets)

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Retrovir (oral/injection), Retrovir

What is Retrovir (Zidovudine Capsules and Tablets)?

Septra

Generic Name: sulfamethoxazole / trimethoprim

Brand name: Septra, Septra DS, Bactrim, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim Pediatric, Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric

Synonyms: n.a.

What is Septra?