Retrovir (Zidovudine Syrup) and Tylenol Sinus Congestion/Pain (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets)
Determining the interaction of Retrovir (Zidovudine Syrup) and Tylenol Sinus Congestion/Pain (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Case reports have suggested that the concomitant use of zidovudine and acetaminophen may potentiate the risk of bone marrow suppression and hepatotoxicity; however data have been conflicting. The mechanism is unknown. Until more information is available, patients taking both drugs concurrently should be monitored for the development of hepatotoxicity and bone marrow toxicity.
- Gill PS, Rarick M, Brynes RK, et al "Azidothymidine associated with bone marrow failure in the acquired immunodeficiency syndrome (AIDS)." Ann Intern Med 107 (1987): 502-5
- Sattler FR, Ko R, Antoniskis D, et al "Acetaminophen does not impair clearance of zidovudine." Ann Intern Med 114 (1991): 937-40
- Burger DM, Meenhorst PL, Koks CH, Beijnen JH "Drug interactions with zidovudine." AIDS 7 (1993): 445-60
- Goldsmith JC, Irvine W "Reversible agranulocytosis related to azidothymidine therapy." Am J Hematol 30 (1989): 263-4
- Ameer B "Acetaminophen hepatotoxicity augmented by zidovudine." Am J Med 95 (1993): 342
- Shriner K, Goetz MB "Severe hepatoxicity in a patient receiving both acetaminophen and zidovudine." Am J Med 93 (1992): 94-6
Generic Name: zidovudine
Brand name: Retrovir
Synonyms: Retrovir (oral/injection), Retrovir
Generic Name: acetaminophen / chlorpheniramine / phenylephrine
Brand name: Alka-Seltzer Plus Cold, Comtrex Severe Cold & Sinus, Contac Cold+Flu Maximum Strength, Dristan Cold Multi Symptom Formula, Robitussin Nighttime Nasal Relief, Tylenol Allergy Multi-Symptom, Tylenol Children's Plus Cold, Tylenol Sinus Congestion Nighttime, Contac Cold/Flu Day & Night, Coricidin D Cold/Flu/Sinus, Dristan Cold, Medicidin-D, Onset Forte, Robitussin Peak Cold Nasal Relief, Super Cold Tabs, Super Strength Sinadrin, Tylenol Sinus Congestion/Pain, Cold Relief Plus, EQL Effervescent Plus Cold, GNP Cold Relief Plus, QC Cold Relief Plus
Synonyms: Tylenol Sinus Congestion Nighttime
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Retrovir (Zidovudine Syrup)-Tylenol Sore Throat Nighttime
- Retrovir (Zidovudine Syrup)-Tylenol w/ Codeine
- Retrovir (Zidovudine Syrup)-Tylenol w/Codeine #3
- Retrovir (Zidovudine Syrup)-Tylenol w/Codeine #4
- Retrovir (Zidovudine Syrup)-Tylenol Warming Cold Multi-Symptom Nighttime
- Retrovir (Zidovudine Syrup)-Tylenol Warming Cough & Sore Throat Nightime
- Tylenol Sinus Congestion/Pain (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets)-Retrovir Infusion
- Tylenol Sinus Congestion/Pain (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets)-Retrovir Intravenous
- Tylenol Sinus Congestion/Pain (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets)-Retrovir oral/injection
- Tylenol Sinus Congestion/Pain (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets)-Revatio
- Tylenol Sinus Congestion/Pain (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets)-Revatio Injection
- Tylenol Sinus Congestion/Pain (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets)-Revatio Intravenous