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Rheumatrex Dose Pack and Sapropterin

Determining the interaction of Rheumatrex Dose Pack and Sapropterin and the possibility of their joint administration.

Check result:

Rheumatrex Dose Pack <> Sapropterin

Relevance: 15.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Methotrexate may decrease the effects of sapropterin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Drugs that affect folate metabolism may reduce the efficacy of sapropterin, which is a synthetic form of tetrahydrobiopterin (BH4). Folate antagonists can decrease tetrahydrobiopterin (BH4) levels by inhibiting the enzyme dihydropteridine reductase.

MANAGEMENT: Caution is advised if sapropterin is used in combination with folate antagonists. The potential for diminished pharmacologic effects of sapropterin should be considered.

References

"Product Information. Kuvan (sapropterin)." BioMarin Pharmaceutical Inc, Novato, CA.

Rheumatrex Dose Pack

Generic Name: methotrexate

Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free

Synonyms: Rheumatrex

What is Rheumatrex Dose Pack?

Sapropterin

Generic Name: sapropterin

Brand name: Kuvan

Synonyms: n.a.

What is Sapropterin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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