Rifadin and Trecator

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

RifAMPin may cause liver damage, and taking it with other medications that can also affect the liver such as ethionamide may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: The concomitant use of rifampin with ethionamide may increase the risk of hepatotoxicity, due to additive hepatotoxic effects. Liver damage, jaundice, and fatalities have been reported in patients with leprosy.

MANAGEMENT: Close monthly monitoring for clinical or laboratory evidence of altered hepatic function is recommended. Patients should be advised to promptly report early symptoms of hepatic disease such as fatigue, weakness, malaise, anorexia, nausea, or vomiting. Discontinuation of either or both drugs may be necessary.

Rifadin

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rifadin?

Trecator

Generic Name: ethionamide

Brand name: Trecator, Trecator-SC

Synonyms: n.a.

What is Trecator?