Rifadin and Zepatier

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using grazoprevir together with rifAMPin is not recommended. Combining these medications may significantly reduce the blood levels of grazoprevir, one of the components of your hepatitis C medication. This may make the medication less effective in treating your infection. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: The plasma concentrations of grazoprevir may increase significantly during acute coadministration with rifampin, but decreases after chronic coadministration. The proposed mechanism is rifampin inhibition of organic anion transporting polypeptide (OATP) 1B1-mediated hepatic uptake of grazoprevir initially, followed by induction of CYP450 3A4-mediated metabolism after multiple-dosing. In 12 study subjects, administration of a single 200 mg dose of grazoprevir with a single 600 mg intravenous dose of rifampin resulted in greater than 10-fold increases in grazoprevir peak plasma concentration (Cmax) and systemic exposure (AUC) compared to administration of grazoprevir alone. A single 600 mg oral dose of rifampin administered during multiple-dosing of grazoprevir 200 mg once daily increased the Cmax and AUC of grazoprevir by 6.5- and 8.4-fold, respectively. By contrast, when grazoprevir 200 mg and rifampin 600 mg were both given orally once daily, grazoprevir Cmax and AUC were not significantly altered, but trough plasma concentration (Cmin) was reduced by 90%. High plasma levels of grazoprevir may increase the risk of adverse effects such as alanine aminotransferase (ALT) elevations, whereas low trough levels may reduce viral susceptibility and increase the risk of resistance development. Rifampin 600 mg given orally or intravenously did not have clinically relevant effects on the pharmacokinetics of a single 50 mg dose of elbasvir.

MANAGEMENT Concomitant use of elbasvir-grazoprevir with rifampin is considered contraindicated.

Rifadin

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rifadin?

Zepatier

Generic Name: elbasvir / grazoprevir

Brand name: Zepatier

Synonyms: n.a.

What is Zepatier?