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Rifadin IV and Vibramycin Hyclate

Determining the interaction of Rifadin IV and Vibramycin Hyclate and the possibility of their joint administration.

Check result:

Rifadin IV <> Vibramycin Hyclate

Relevance: 19.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using rifAMPin together with doxycycline may decrease the effects of doxycycline. Contact your doctor if your condition changes or if your infection worsens. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rifamycins may decrease the therapeutic effect of doxycycline. Increased hepatic metabolism of doxycycline by the rifamycin may lead to a decreased serum concentration and half-life of doxycycline.

MANAGEMENT: Monitor the patient for decreased clinical effect and increase the dose of doxycycline if needed.

References

Colmenero JD, Fernandezgallardo LC, Agundez JAG, Sedeno J, Benitez J, Valverde E "Possible implications of doxycycline-rifampin interaction for treatment of brucellosis." Antimicrob Agents Chemother 38 (1994): 2798-802
"Product Information. Mycobutin (rifabutin)." Pharmacia and Upjohn, Kalamazoo, MI.
"Product Information. Rifadin (rifampin)." Hoechst Marion-Roussel Inc, Kansas City, MO.

Rifadin IV

Generic Name: rifampin

Brand name: Rifadin IV, Rifadin, Rimactane

Synonyms: n.a.

What is Rifadin IV?

Vibramycin Hyclate

Generic Name: doxycycline

Brand name: Acticlate, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, TargaDOX, Vibramycin, Doxy 100, TargaDOX

Synonyms: Doxycycline

What is Vibramycin Hyclate?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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